REAL-WORLD USE OF ORPHAN MEDICINAL PRODUCTS (OMPS) IN RARE DISEASE (RD) PATIENTS: A POPULATION-BASED REGISTRY STUDY

Real-world use of orphan medicinal products (OMPs) in rare disease (RD) patients: A population-based registry study

Background: Despite calls for the use of real-world data, the rare diseases (RD) treatment landscape suffers from a scarcity of data referred to orphan medicinal products (OMP) Hibiscus use at the population level.Objectives: We aim to describe the characteristics and patterns of utilization of OMP in a sizable group of RD patients globally monitor

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Biobank Digitalization: From Data Acquisition to Efficient Use

Biobanks are involved in a broad range of studies, including both basic and clinical research, so their functions and roles are evolving.Digital biobanks have emerged due to digitalization in this field; however, it also entails an Large Leg Desk increasing number of ethical and legal issues, in particular those related to the protection of donor d

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Photomechanical wave-driven delivery of siRNAs targeting intermediate filament proteins promotes functional recovery after spinal cord injury in rats.

The formation of glial scars after spinal cord injury (SCI) is one of the factors inhibiting Rocker Panel axonal regeneration.Glial scars are mainly composed of reactive astrocytes overexpressing intermediate filament (IF) proteins such as glial fibrillary acidic protein (GFAP) and vimentin.In the current study, we delivered small interfering RNAs

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Climatic variation along the distributional range in Cuban Anolis lizards: Species and ecomorphs under future scenarios of climate change

Geographical ranges and physiological tolerances of species are correlated, and it can be expected that widespread species encounter higher climatic variation across their distributions than restricted species.Widespread species should consequently be more tolerant to extreme or variable weather conditions, and may have the ability to better conser

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